NOTCH4 mRNA NOTCH4 gene transcription Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14 Edited: D'Eustachio, P, 2012-02-06 Edited: D'Eustachio, P, 2012-05-15 Edited: Orlic-Milacic, M, 2012-02-10 Pubmed15684396 Pubmed9693032 Reactome Database ID Release 431912401 Reactome, http://www.reactome.org ReactomeREACT_118639 Reviewed: Haw, R, 2012-02-06 Reviewed: Haw, R, 2012-05-17 The NOTCH4 gene maps to the short arm of human chromosome 6. High levels of NOTCH4 transcript are detectable in adult heart. NOTCH4 mRNA is also found in lung and placenta, and at low levels in liver, skeletal muscle, kidney, pancreas, spleen, thymus, lymph nodes and bone marrow (Li et al. 1998).<br><br>In vascular endothelium, NOTCH4 transcription is activated by c-JUN (AP-1) transcription factor. JUN, likely in complex with other transcription factors, binds AP-1 motif(s) in the NOTCH4 promoter and possibly within the first intron (Wu et al. 2005). NOTCH4 gene