NOTCH3 mRNA NOTCH3 gene transcription Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14 Edited: D'Eustachio, P, 2012-02-06 Edited: D'Eustachio, P, 2012-05-15 Edited: Orlic-Milacic, M, 2012-02-10 Pubmed19150886 Pubmed8878478 Reactome Database ID Release 431912415 Reactome, http://www.reactome.org ReactomeREACT_118757 Reviewed: Haw, R, 2012-02-06 Reviewed: Haw, R, 2012-05-17 The NOTCH3 gene maps to human chromosome 19. NOTCH3 transcript is ubiquitously expressed in fetal and adult human tissues. Mutations in NOTCH3 are found in cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an autosomal dominant progressive disorder of small arterial vessels of the brain characterized by migraines, strokes, and white matter lesions, with the onset in early adulthood (Joutel et al. 1996).<br><br>NOTCH3 gene transcription is stimulated by the NOTCH3 coactivator complex but it is not known whether this effect is direct, or indirect (Liu et al. 2009). NOTCH3 gene