NOTCH1 mRNA miR-449 RISC NOTCH1 mRNA:miR-449 RISC MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14 Edited: D'Eustachio, P, 2012-02-06 Edited: Gillespie, ME, 2012-02-09 Edited: Jupe, S, 2011-09-27 Edited: May, B, 2012-02-09 Edited: Orlic-Milacic, M, 2012-02-10 Pubmed21602795 Reactome Database ID Release 431606561 Reactome, http://www.reactome.org ReactomeREACT_118755 Reviewed: Haw, R, 2012-02-06 Translation of NOTCH1 mRNA is negatively regulated by MIR449 microRNAs (MIR449A, MIR449B and MIR449C), which bind to the 3'UTR of NOTCH1. Downregulation of NOTCH1 signaling by the MIR449 cluster appears to be an evolutionarily conserved mechanism involved in regulation of vertebrate multiciliogenesis. DLL1 mRNA is also a target of the MIR449 cluster.