NOTCH1/Fringe-modified NOTCH1 DLL1:NOTCH1 NOTCH1 binds DLL1 Authored: Jassal, B, 2004-12-15 13:08:03 Edited: D'Eustachio, P, 2012-02-06 Edited: Orlic-Milacic, M, 2012-02-10 Pubmed15574878 Pubmed18296446 Pubmed9819428 Reactome Database ID Release 431980039 Reactome, http://www.reactome.org ReactomeREACT_118603 Reviewed: Haw, R, 2012-02-06 Reviewed: Joutel, A, 2004-12-15 The NOTCH1 receptor is activated by binding a Delta-like 1 ligand (DLL1), presented on the plasma membrane of a neighboring cell (Jarriault et al. 1998). EGF repeat 12 (EGF12) in the extracellular domain of NOTCH1 appears to be particularly important for interaction of NOTCH1 with DLL1 (Cordle et al. 2008). The affinity of NOTCH1 for DLL1 is increased when NOTCH1 is glycosylated by fringe enzymes (Yang et al 2005).