JAG1:NOTCH1 NOTCH1 NOTCH1 binds JAG1 Authored: Jassal, B, 2004-12-15 13:08:03 Edited: D'Eustachio, P, 2012-02-06 Edited: Orlic-Milacic, M, 2012-02-10 NOTCH1 is activated by JAG1 ligand expressed on a neighboring cell. Based on mouse studies, activation of NOTCH1 by JAG1 may be important in angiogenesis (Benedito et al. 2009). In addition, human JAG1 was shown to inhibit granulocytic differentiation of 32D mouse myeloid progenitors expressing Notch1 (Li et al. 1998). Pubmed19524514 Pubmed9462510 Reactome Database ID Release 431980042 Reactome, http://www.reactome.org ReactomeREACT_118661 Reviewed: Haw, R, 2012-02-06 Reviewed: Joutel, A, 2004-12-15