Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH Sia-Gal-GlcNAc-NOTCH Fringe-modified Pre-NOTCH is cleaved by FURIN Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14 Cleavage of fringe-modified NOTCH by FURIN has not been examined directly, but since mature, plasma membrane-anchored NOTCH receptors are typically cleaved by FURIN (Blaumueller et al. 1997) and fringe-modified NOTCH functions at the cell surface (Moloney et al. 2000), it is expected that fringe-modified NOTCH is processed by FURIN cleavage. The exact order of fringe-mediated glycosylation and FURIN cleavage has not been experimentally established, but since FURIN localizes to the trans-Golgi network -TGN (Teuchert et al. 1999), while fringe has not been associated with TGN, it is likely that modification of NOTCH by fringe enzymes precedes FURIN-mediated cleavage. EC Number: 3.4.21 Edited: D'Eustachio, P, 2012-02-06 Edited: Orlic-Milacic, M, 2012-02-10 Pubmed10075724 Pubmed10935626 Pubmed9244302 Reactome Database ID Release 431912372 Reactome, http://www.reactome.org ReactomeREACT_118767 Reviewed: Haw, R, 2012-02-06