Bradykinin receptor Bradykinin receptor:Bradykinin Bradykinin receptors B1 and B2 bind to bradykinin Authored: Jassal, B, 2008-08-21 14:07:16 Bradykinin (Rocha e Silva M, et al, 1949) is a 9 amino-acid peptide belonging to the kinin group of proteins. It causes blood vessel dilation via the release of prostacyclin, nitric oxide and endothelial-derived hyperpolarizing factor, resulting in lower blood pressure. It is also involved in the pain mechanism. Bradykinin exerts its effects through two receptors, bradykinin receptor B1 and 2 (B1R and B2R respectively). B1R (Menke JG et al, 1994) is synthesized de novo following tissue injury and receptor binding leads to an increase in cytosolic calcium concentration, resulting in chronic and acute inflammatory responses. Unlike B1R, B2R (Hess JF et al, 1992) is ubiquitously and constitutively expressed in healthy tissues. It also increase cytosolic calcium concentration and stimulates the mitogen-activated protein kinase pathways. Edited: D'Eustachio, P, 2008-09-01 11:58:31 Pubmed1314587 Pubmed18127230 Pubmed3366244 Pubmed8063797 Reactome Database ID Release 43374331 Reactome, http://www.reactome.org ReactomeREACT_14852 Reviewed: Bockaert, J, 2008-09-01 12:04:13