CDK8:CCNC PCAF MAML NOTCH1 Coactivator Complex:CDK8:CCNC RBPJ:SNW1 NICD1 is phosphorylated by CDK8 Authored: Egan, SE, Orlic-Milacic, M, 2011-11-14 CDK8 phosphorylates conserved serine residues in the TAD and PEST domains of NICD1. Phosphorylation targets NICD1 for ubiquitination and degradation, ultimately terminating transcriptional activity of NOTCH1. EC Number: 2.7.11.22 Edited: D'Eustachio, P, 2012-02-06 Edited: Orlic-Milacic, M, 2012-02-10 Pubmed15546612 Reactome Database ID Release 431912391 Reactome, http://www.reactome.org ReactomeREACT_118660 Reviewed: Haw, R, 2012-02-06