11-deoxycorticosterone is oxidised to corticosterone by CYP11B2 Authored: Jassal, B, 2008-05-19 12:57:01 EC Number: 1.14.15.4 Edited: Jassal, B, 2008-05-19 12:57:01 P450 11B2 (steroid 11 beta-hydroxylase) is a mitochondrial cytochrome P-450 enzyme necessary for cortisol biosynthesis.The synthesis of the most important glucocorticoid and mineralocorticoid hormones in humans (cortisol and aldosterone, respectively), take place in the adrenal gland. The 11?- and 18-hydroxylation of the substrate 11-deoxycorticosterone (DOC) leads to corticosterone (B)band 18-hydroxycorticosterone (18-OH-B), whose 18-oxidation yields aldosterone. CYP11B1 is also able to produce corticosterone from 11-deoxycorticosterone but it cannot convert corticosterone into aldosterone. Pubmed11856349 Pubmed2592361 Reactome Database ID Release 43211955 Reactome, http://www.reactome.org ReactomeREACT_13700 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54