Spermine is oxidized to spermidine Authored: Gopinathrao, G, 2008-05-21 15:52:50 Edited: Gopinathrao, G, 2006-04-27 13:13:48 Pubmed11454677 Pubmed12141946 Pubmed12727196 Reactome Database ID Release 43141341 Reactome, http://www.reactome.org ReactomeREACT_2194 Reviewed: D'Eustachio, P, 2008-06-12 14:43:38 Spermine oxidase (SMOX/PAOh1/SMO) is a polyamine oxidase flavoenzyme which catalyzes the oxidation of spermine to spermidine. It plays an important role in the regulation of endogenous polyamine intracellular concentration. Five different isozymes are produced by alternative splicing with isozyme 3 being the major isoform and possessing the highest affinity for spermine. It is highly inducible by specific antitumor polyamine analogues (Wang et al., 2001).