NQO1 interaction with ODC A novel pathway has been described for ODC degradation during oxidative stress, which is regulated by NAD(P)H quinone oxidoreductase (NQO1). In this pathway, the 20S proteasome has been shown to degrade unfolded ODC monomers. This event does not require the COOH-terminal domain. NQO1 binds to ODC and stabilizes it. If this interaction is disrupted with dicoumarol, it sensitizes ODC monomers to degradation by the 20S proteasome independent of both antizyme and ubiquitin. The details of the role of this pathway remains to be determined, but it could be involved in the nascent ODC chain turnover. Authored: Gopinathrao, G, 2008-05-19 18:50:15 Pubmed12653649 Pubmed15749015 Pubmed16205122 Pubmed16459331 Reactome Database ID Release 43350578 Reactome, http://www.reactome.org ReactomeREACT_13453 Reviewed: D'Eustachio, P, 2008-06-12 17:57:32 ODC:NQO1 complex