Monoiodinated tyrosine can be deiodinated Authored: Jassal, B, 2008-10-01 13:18:42 EC Number: 1 Edited: Jassal, B, 2008-01-08 13:51:41 Pubmed16910871 Reactome Database ID Release 43209921 Reactome, http://www.reactome.org ReactomeREACT_15389 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).