glyoxylate + alanine => glycine + pyruvate [peroxisome] Alanine-glyoxylate transaminase (AGXT) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Danpure and Jennings 1988). The active form of the enzyme is a homodimer (Zhang et al. 2003) with one molecule of pyridoxal phosphate bound to each subunit (Coulter-Mackie et al. 2005). Mutations in this enzyme are associated with primary hyperoxaluria type I. Mutant alleles encode both catalytically inactive proteins and active ones that are mis-localized to mitochondria (Purdue et al. 1990; Takada et al. 1990). Authored: D'Eustachio, P, 2009-01-11 19:48:01 EC Number: 2.6.1.44 Edited: D'Eustachio, P, 2009-03-03 14:28:53 Pubmed12899834 Pubmed15802217 Pubmed1703535 Pubmed2363689 Pubmed3416563 Reactome Database ID Release 43389684 Reactome, http://www.reactome.org ReactomeREACT_16972 Reviewed: Jassal, B, 2009-03-03 14:29:24