HER4 NRGs/EGF-like ligands NRGs/EGFLs:ERBB4 ERBB4 binds NRGs or EGF-like ligands All three ERBB4 isoforms are activated by binding of neuregulins (NRG1, NRG2, NRG3 and NRG4) or EGF like growth factors (betacellulin, epiregulin, HB EGF) to their extracellular domain. Authored: Orlic-Milacic, M, 2011-11-04 ERBB4 binds neuregulins or EGF-like ligands Edited: Matthews, L, 2011-11-07 NRGs/EGF-like ligands + ERBB4 => NRGs/EGF-like ligands:ERBB4 Pubmed17545517 Pubmed7929212 Pubmed9135143 Pubmed9168115 Pubmed9275162 Pubmed9556621 Reactome Database ID Release 431236398 Reactome, http://www.reactome.org ReactomeREACT_115812 Reviewed: Earp HS, 3rd, 2012-02-20 Reviewed: Harris, RC, 2011-11-11 Reviewed: Misior, AM, 2012-02-20 Reviewed: Zeng, F, 2011-11-11 has a Stoichiometric coefficient of 3