NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PIK3R1 Phosphorylated ERBB2:ERBB4cyt1 heterodimers Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB2:p-ERBB4 CYT-1 heterodimers Authored: Orlic-Milacic, M, 2011-11-04 Edited: Matthews, L, 2011-11-07 Pubmed18721752 Pubmed8617750 Reactome Database ID Release 431250346 Reactome, http://www.reactome.org ReactomeREACT_115895 Reviewed: Neckers, LM, 2011-11-11 Reviewed: Xu, W, 2011-11-11 p85 subunit of PI3K (PIK3R1) directly binds to any of the two phosphorylated ERBB4 CYT1 isoforms in complex with ERBB2 through interaction with a phosphorylated tyrosine residue in the C-tail of ERBB4 CYT1 (Y1056 in ERBB4 JM-A CYT1; Y1046 in ERBB4 JM-B CYT1).