Phosphorylated ERBB2 heterodimers SHC1:Phosphorylated ERBB2 heterodimers SHC1 binds phosphorylated ERBB2 heterodimers Authored: Orlic-Milacic, M, 2011-11-04 Edited: Matthews, L, 2011-11-07 Pubmed18721752 Pubmed8617750 Pubmed8665853 Reactome Database ID Release 431963578 Reactome, http://www.reactome.org ReactomeREACT_116025 Reviewed: Neckers, LM, 2011-11-11 Reviewed: Xu, W, 2011-11-11 SHC1 binds phosphorylated ERBB2:EGFR heterodimers through phosphorylated tyrosine residues on either ERBB2 (Y1196, Y1221, Y1222 and Y1248) or EGFR (Y1148 and Y1173). Heterodimers of ERBB2 and ERBB3 recruit SHC1 through a phosphorylated tyrosine residue Y1328 in the C-tail of ERBB3. Heterodimers of ERBB2 and ERBB4 isoforms recruit SHC1 through phosphorylated tyrosines in the C-tail of etiher ERBB2 (Y1196, Y1221, Y1222 and Y1248) or ERBB4 (Y1188 and Y1242 in ERBB4 JM-A CYT1 isoform; Y1178 and Y1232 in ERBB4 JM-B CYT1 isoform; Y1172 and Y1226 in ERBB4 JM-A CYT2 isoform). Association of SHC1 with ERBB2:EGFR and ERBB2:ERBB3 heterodimers was demonstrated in engineered mouse 32D cells in which human ERBB2, EGFR and ERBB3 were expressed. Therefore, these experiments showed association of human ERBB receptor dimers and mouse Shc1. In the case of ERBB2:ERBB4 heterodimers, direct evidence, involving human proteins only, is available.