ERBB2 heterodimers p-Y877-ERBB2 heterodimers SRC family kinases phosphorylate ERBB2 Authored: Orlic-Milacic, M, 2011-11-04 Dissociation of HSP90 from ERBB2 upon formation of ERBB2 heterodimers (with either EGFR, ERBB3 or ERBB4) enables phosphorylation of ERBB2 on the tyrosine residue Y877, mediated by one of SRC family kinases - SRC, FYN or YES1. Although not a mandatory prerequisite of ERBB2 catalytic activity, the phosphorylation at Y877 significantly increases the kinase activity of ERBB2. EC Number: 2.7.10 Edited: D'Eustachio, P, 2011-11-07 Pubmed17030621 Reactome Database ID Release 431963586 Reactome, http://www.reactome.org ReactomeREACT_115797 Reviewed: Neckers, LM, 2011-11-11 Reviewed: Xu, W, 2011-11-11