PRLR ligands:p(Y611)-PRLR:p(Y1007)-JAK2 dimer:p-STAT5 PRLR ligands:p(Y611)-PRLR:p(Y1007)-JAK2:STAT5 PRLR-bound STAT5 is phosphorylated Authored: Jupe, S, 2011-06-13 Co-immunoprecipitation of rat Stat5 and Prlrs mutated to have a single intracellular tyrosine suggests that phosphorylation of these tyrosines is required for Stat5 binding and leads to Stat5 tyrosine phosphorylation (Pezet et al. 1997). STAT1 and STAT3 have both been reported to be activated by PRLR (DaSilva et al. 1996), but the region(s) of PRLR required for activation of these Stats remains poorly documented. EC Number: 2.7.10 Edited: Jupe, S, 2011-10-17 Pubmed8737372 Pubmed9312112 Reactome Database ID Release 431671691 Reactome, http://www.reactome.org ReactomeREACT_115938 Reviewed: Goffin, V, 2011-11-08 has a Stoichiometric coefficient of 2