PRLR ligands:Activated PRLR:p(Y1007)-JAK2 dimer PRLR ligands:p(Y611)-PRLR:p(Y1007)-JAK2 dimer Tyrosine phosphorylation of PRLR Authored: Jupe, S, 2011-06-13 Edited: Jupe, S, 2011-10-17 Pubmed7537382 Pubmed9312112 Reactome Database ID Release 431364043 Reactome, http://www.reactome.org ReactomeREACT_116161 Reviewed: Goffin, V, 2011-11-08 The model for PRL-induced PRLR activation suggests that JAK2 phosphorylates PRLR on specific tyrosine residues. Consistent with this, JAK2 and PRLR are phosphorylated in response to activating ligand (Lebrun et al. 1994) and PRLR tyrosine phosphorylation is required for subsequent Stat signaling (Pezet et al. 1997). Though this evidence is consistent with a role for JAK2, it has not been formally demonstrated that JAK2 is the kinase responsible for PRLR tyrosine phosphorylation. has a Stoichiometric coefficient of 2