SCF beta-TrCP complex PRLR ligands:p(S349)- PRLR:JAK2 dimer:SCF beta-TrCP complex PRLR ligands:p(S349)- PRLR:JAK2 dimer:SCF beta-TrCP complex Prolactin receptor is internalized Authored: Jupe, S, 2011-06-13 Edited: Jupe, S, 2011-10-17 PRLR is regulated by ubiquitination of the activated receptor, leading to lysosomal degradation (Djiane et al. 1981, 1982, Lu et al. 2002). Recruitment of the SCFbeta-TrCP ubiquitin ligase complex enables receptor ubiquitination and internalization (Li et al. 2004). This limits the duration and intensity of receptor signaling. Deregulation of this negative control lead to pathological conditions including cancer (Swaminathan et al. 2008). Pubmed12403840 Pubmed15082796 Pubmed18204982 Pubmed6275396 Pubmed6276249 Reactome Database ID Release 431170539 Reactome, http://www.reactome.org ReactomeREACT_115907 Reviewed: Goffin, V, 2011-11-08