PRLR ligands:p(S349)-PRLR:JAK2 dimer PRLR ligands:Activated PRLR:JAK2 dimer PRLR is phosphorylated at Ser-349 Authored: Jupe, S, 2011-06-13 Edited: Jupe, S, 2011-10-17 Pubmed12403840 Pubmed15082796 Pubmed16278670 Pubmed6275396 Pubmed6276249 Reactome Database ID Release 431370505 Reactome, http://www.reactome.org ReactomeREACT_115844 Reviewed: Goffin, V, 2011-11-08 The PRL responsiveness of target cells is negatively regulated by receptor internalization, ubiquitination and degradation, which limit the duration and intensity of receptor signaling (Djiane et al. 1981, 1982, Lu et al. 2002). The PRLR is phosphorylated on Ser-349 by an unidentified kinase (Li et al. 2006) enabling subsequent recruitment of the SCF beta-TrCP ubiquitin ligase complex (Li et al. 2004). has a Stoichiometric coefficient of 2