E4ICD ERBB4s80:WWOX WWOX binds ERBB4s80 Authored: Orlic-Milacic, M, 2011-11-04 Edited: Matthews, L, 2011-11-07 Pubmed16061658 Pubmed19047365 Reactome Database ID Release 431253343 Reactome, http://www.reactome.org ReactomeREACT_115707 Reviewed: Earp HS, 3rd, 2012-02-20 Reviewed: Harris, RC, 2011-11-11 Reviewed: Misior, AM, 2012-02-20 Reviewed: Zeng, F, 2011-11-11 WWOX binds to ERBB4s80 through WW-domain binding motifs in the C-tail of ERBB4. Formation of ERBB4s80:WWOX complex competes with the formation of ERBB4:YAP1 complex and prevents translocation of ERBB4s80 to the nucleus. Feng et al. established that WWOX binds with the same affinity to s80CYT1 and s80CYT2, and identified PY3 as the most important WW-domain binding motif for WWOX binding.