ERBB4 homodimers p-ERBB4 homodimers Trans-autophosphorylation of ERBB4 homodimers Authored: Orlic-Milacic, M, 2011-11-04 EC Number: 2.7.10 Edited: Matthews, L, 2011-11-07 Homodimers of ERBB4 CYT 1 isoforms trans autophosphorylate on six tyrosine residues (three on each monomer) that serve as docking sites for SHC1 (tyrosines Y1188 and 1242 in the isoform ERBB4 JM-A CYT1; tyrosines Y1178 and Y1232 in the isoform ERBB4 JM-B CYT1) and the p85 subunit of PI3K (tyrosine Y1056 in the isoform ERBB4 JM-A CYT1; tyrosine Y1046 in the isoform ERBB4 JM-B CYT1), while ERBB4 CYT2 isoform homodimer trans-autophosphorylates on four SHC1 binding tyrosines (two on each monomer - tyrosines Y1172 and Y1226). Pubmed18721752 Pubmed8617750 Reactome Database ID Release 431250315 Reactome, http://www.reactome.org ReactomeREACT_115989 Reviewed: Earp HS, 3rd, 2012-02-20 Reviewed: Harris, RC, 2011-11-11 Reviewed: Misior, AM, 2012-02-20 Reviewed: Zeng, F, 2011-11-11 has a Stoichiometric coefficient of 16