p-2S-SMAD1/5/8 BMP:p-BMPR:Endofin BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 Phospho-R-Smad1/5/8 dissociates from the receptor complex Authored: Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00 Pubmed15350224 Pubmed17356069 Pubmed8893010 Pubmed8980228 Pubmed9136927 Pubmed9311995 Pubmed9346966 Reactome Database ID Release 43201453 Reactome, http://www.reactome.org ReactomeREACT_12069 Reviewed: Heldin, CH, 2007--1-1- Upon phosphorylation of the R-SMAD (SMAD2/3), the conformation of the C-terminal (MH2) domain of the R-SMAD changes, lowering its affinity for the type I receptor and SARA. As a result, the phosphorylated R-SMAD dissociates from the activated receptor complex (TGFBR).