GDI proteins RhoGTPase:GDP Inactivated RhoGTPase:GDP:GDI complex GDIs block activation of Rho GTPase:GDP Authored: Van Aelst, L, 2007-04-28 21:26:24 Edited: Gopinathrao, G, 2007-04-02 21:35:36 GDP dissociation inhibitors or GDIs confer an additional but important layer of Rho GTPase regulation along with GEFs and GAPs. GDIs mainly inhibit the dissociation of bound guanine nucleotide (usually GDP) from their partner GTPases. So far, three human GDIs with proven biological functions have been found: RhoGDI/GDIalpha/GDI1, hematopoietic cell selective Ly/D4GDI/GDIbeta/GDI2, and Rho GDIgamma/GDI3 (DerMardirossian and Bokoch, 2005). Three specific biochemical functions of GDIs have been established: inhibiting the dissociation of GDP from Rho proteins, maintaining the GTPases in an inactive form, and preventing GTPase activation by GEFs (Olofsson, 1999). Detailed annotations of GDIs will be available in future releases. Pubmed10433515 Pubmed10655614 Pubmed10676816 Pubmed1439791 Pubmed15292224 Pubmed15921909 Pubmed16190977 Pubmed7543319 Pubmed7824266 Pubmed9113980 Pubmed9194563 Reactome Database ID Release 43194854 Reactome, http://www.reactome.org ReactomeREACT_10055 Reviewed: Bernards, A, 2007-04-28 21:27:12