effector proteins RhoGTPase:GTP:Effectors complex RhoGTPase:GTP Rho GTPase:GTP activates downstream effectors Authored: Van Aelst, L, 2007-04-28 21:26:24 Edited: Gopinathrao, G, 2007-04-02 21:35:36 Pubmed10360578 Pubmed11130076 Pubmed11157984 Pubmed11738596 Pubmed12423633 Pubmed12429845 Pubmed12504591 Pubmed15260990 Pubmed15611088 Pubmed15630019 Pubmed15821030 Pubmed9308960 Reactome Database ID Release 43194894 Reactome, http://www.reactome.org ReactomeREACT_10126 Reviewed: Bernards, A, 2007-04-28 21:27:12 To transduce signals, the activated, GTP-bound Rho GTPases interact with specific effector molecules. It has been observed that GEFs contribute to the signaling specificity of their downstream target GTPase via association with scaffolding molecules that link them and the GTPase to specific GTPase effectors (Govek et al., 2005). Some of the effector molecules implicated in actin and microtubule dynamics include diaphanous-related formins, Toca 1, WIP, WASP, Pak, p35/Cdk5, Wave, Nap125, MLCK, MLC, IRSp53. Detailed annotations of the downstream events stimulated by activated, GTP bound Rho GTPases will be available in future releases.