ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate Authored: D'Eustachio, P, 2003-06-24 00:00:00 Cytosolic argininosuccinate synthase catalyzes the reaction of aspartate, citrulline, and ATP to form argininosuccinate, AMP, and pyrophosphate. The function of the human enzyme in vivo is inferred from the hypercitrullinemia observed in patients with defective forms of the enzyme (e.g., Engel et al. 2009). The enzyme is active as a homotetramer (O’Brien 1980; Karlberg et al. 2008). EC Number: 6.3.4.5 Edited: D'Eustachio, P, 2003-06-24 00:00:00 Pubmed18323623 Pubmed19006241 Pubmed518841 Reactome Database ID Release 4370577 Reactome, http://www.reactome.org ReactomeREACT_482