trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2 EC Number: 1.14.11.8 Pubmed11431483 Reactome Database ID Release 4371241 Reactome, http://www.reactome.org ReactomeREACT_1814 Trimethyllysine dioxygenase dimer (TMLHE) in the mitochondrial matrix catalyzes the reaction of oxygen, 2-oxoglutarate, and 'N6,N6,N6-Trimethyl-L-lysine to form CO2, 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine, and succinate (Vaz et al. 2001).