tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate Authored: D'Eustachio, P, 2003-06-24 00:00:00 Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate and glutamate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer. EC Number: 2.6.1.5 Edited: D'Eustachio, P, 2003-06-24 00:00:00 ISBN0079130356 Reactome Database ID Release 4371155 Reactome, http://www.reactome.org ReactomeREACT_690