L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+ Authored: D'Eustachio, P, 2003-06-24 00:00:00 EC Number: 1.5.1.12 Edited: D'Eustachio, P, 2003-06-24 00:00:00 Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) catalyzes the reaction of L-glutamate gamma-semialdehyde and NAD+ to form glutamate and NADH + H+ (Hu et al. 1996). The enzyme is a dimer (Forte-McRobbie and Pietruszko 1986). ALDH4A1 mutations cause type II hyperprolinemia in vivo (Geraghty et al. 1998). Pubmed3944130 Pubmed8621661 Pubmed9700195 Reactome Database ID Release 4370679 Reactome, http://www.reactome.org ReactomeREACT_2180