pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] Authored: D'Eustachio, P, 2010-02-18 EC Number: 2.6.1.2 Edited: D'Eustachio, P, 2010-02-18 Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009). Pubmed11863375 Pubmed19360321 Reactome Database ID Release 43507749 Reactome, http://www.reactome.org ReactomeREACT_21311 Reviewed: Jassal, B, 2010-02-26