Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] Authored: D'Eustachio, P, 2008-09-12 21:47:19 Edited: D'Eustachio, P, 2008-09-12 21:47:19 Pubmed11083877 Reactome Database ID Release 43372480 Reactome, http://www.reactome.org ReactomeREACT_14838 SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, mediates the exchange of 2-oxoadipate and 2-oxoglutarate across the inner mitochondrial membrane. While the exchange is reversible, under physiological conditions it proceeds in the direction of 2-oxoadipate import into the mitochondrial matrix and 2-oxoglutarate export (Fiermonte et al. 2001).