alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010). Authored: D'Eustachio, P, 2003-06-24 00:00:00 EC Number: 1.2.1.31 Edited: D'Eustachio, P, 2003-06-24 00:00:00 Pubmed16491085 Pubmed19885858 Reactome Database ID Release 4370941 Reactome, http://www.reactome.org ReactomeREACT_1540