a-ketoisocaproate, a-keto b-methylvalerate, a-ketoisovalerate Leu, Ile, Val leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] EC Number: 2.6.1.42 Mitochondrial branched-chain-amino-acid aminotransferase (BCAT2) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate (Bledsoe et al. 1997). The active enzyme is a homodimer (Yennawar et al. 2001, 2002). In the body, this enzyme is widely expressed but is especially abundant in muscle tissue. Pubmed11264579 Pubmed12269802 Pubmed9165094 Reactome Database ID Release 4370724 Reactome, http://www.reactome.org ReactomeREACT_2034