isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 EC Number: 1.3.99.10 Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997). Pubmed3597357 Pubmed6928646 Pubmed9214289 Reactome Database ID Release 4370745 Reactome, http://www.reactome.org ReactomeREACT_1586