RPA-coated 3'-ends of DNA double strand break 3' ends of DNA double strand break RPA heterotrimer Association of RPA complexes with ssDNA Authored: Matthews, L, 2003-09-10 06:00:00 Human replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein required for DNA replication, recombination, and repair. RPA is a stable heterotrimer consisting of subunits with molecular masses of 14, 32 and 70 kDa (p14, p32 and p70, respectively). Association of RPA with ssDNA is thought to contribute to both the protection and removal of secondary structure from single-stranded DNA. Pubmed11080452 Reactome Database ID Release 4375994 Reactome, http://www.reactome.org ReactomeREACT_2149