Ku:DNA double-strand break ends Ku70:Ku80 heterodimer DNA double-strand break ends Association of Ku heterodimer with ends of DNA double-strand break Authored: Matthews, L, 2003-09-07 08:47:00 Ionizing radiation (IR) induces single-strand breaks i.e. cleavage of the phosphodiester backbone. When two single-strand breaks occur within approximately 10 base pairs, a DNA double-strand break results. IR-induced DSBs are complex DNA damage lesions, containing base damage and frequently containing 5'-OH groups and 3'-hydroxy or phosphoglycolate groups that must be removed prior to ligation in the final step of NHEJ (Friedberg et al, 1995; Nikjoo et al, 2001; Valerie and Povirk, 2003). The Ku70/80 heterodimer (Walker et al., 2001) binds to the ends of the double-strand break. Ku can translocate inwards from the site of the break in an ATP-independent manner (reviewed in Dynan and Yoo, 1998). Pubmed11493912 Pubmed11604075 Pubmed12947387 Pubmed9512523 Reactome Database ID Release 4375917 Reactome, http://www.reactome.org ReactomeREACT_1854