Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB Authored: Matthews, L, 2003-08-11 05:43:00 H2AX phosphorylation (producing the gamma-H2AX protein form) occurs within 1-3 minutes of DNA damage (Rogakou et al,1998) and is promoted by MDC1/NFBD1 (Stewart et al., 2003). gamma H2AX is one of the first proteins to appear at the site of damage, localizing to a region of about 2 Mbp surrounding the site of the double-strand break (Rogakou et al,1998). gamma-H2AX appears to play an essential role in recruiting other repair proteins including Rad50, Rad51 and BRCA1(Paull et al., 2000) (Stewart et al., 2003). Pubmed10959836 Pubmed12607005 Pubmed9488723 Reactome Database ID Release 4375242 Reactome, http://www.reactome.org ReactomeREACT_1517