cholesterol + PAPS => cholesterol sulfate + PAP EC Number: 2.8.2.2 Edited: D'Eustachio, P, 2006-03-11 18:40:17 Pubmed11416019 Pubmed12145317 Pubmed12730293 Reactome Database ID Release 43176609 Reactome, http://www.reactome.org ReactomeREACT_6957 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 The 3-hydroxyl groups of a number of sterols can undergo sulfonation. Cholesterol sulfate is particularly abundant in the body, and may have both regulatory and biosynthetic functions (Strott and Higashi 2003). Its synthesis is catalyzed by the b isoform of SULT2B1 (Fuda et al. 2002; Javitt et al. 2001).