CYP2W1 can oxidize indole Authored: Jassal, B, 2008-05-19 12:57:01 CYP2W1 is a so-called "ophan P450", a P450 which has no defined function or endogenous/xenobiotic substrates. CYP2W1 has recently been shown to be selectively expressed in some forms of cancers and, with the low expression in normal tissues, could be rendered as a possible drug target during cancer therapy (Karlgren M, Ingelman-Sundberg M, 2007). CYP2W1 can bioactivate several procarcinogens but at lower levels than other P450s (Wu, ZL et al, 2006). CYP2W1 also shows monooxygenase activity towards the pigment indole, an ingredient of perfumes and coal tar. Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed16551781 Pubmed16677611 Pubmed17150034 Reactome Database ID Release 43211968 Reactome, http://www.reactome.org ReactomeREACT_13592 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54