CYP2U1 can omega-hydroxylate arachidonate A novel cytochrome P450, CYP2U1, may play an important role in modulating the arachidonic acid signaling pathway. It was discovered by searching the human EST database for homology to existing CYPs and subsequent cloning and expression to obtain the enzyme. CYP2U1 was found to be highly expressed in the thymus and the brain (cerebellum) and found to metabolize arachidonic acid to 19- and 20-hydroxy-modified arachidonic acids. It is thought that CYP2U1 plays an important physiological role in fatty acid signaling processes in both the cerebellum and thymus. The omega-hydroxylation (19) example is provided here. Authored: Jassal, B, 2008-05-19 12:57:01 Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed14660610 Reactome Database ID Release 43211960 Reactome, http://www.reactome.org ReactomeREACT_13412 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54