CYP2S1 can deactivate all-trans-retinoic acid Authored: Jassal, B, 2008-05-19 12:57:01 CYP2S1 is a recently discovered cytochrome P450 enzyme on the basis of homology searches of databases and was found to be homologous to the CYP2 family of enzymes that are known to metabolize xenobiotics (Rylander T et al, 2001). CYP2S1 is expressed in skin cells and is inducible by UV radiation, coal tar and all-trans retinoate, the latter also serving as a substrate for the enzyme. Expression of CYP2S1 was significantly higher in psoriatic plaque than in normal skin. Psoriasis is a chronic hyperproliferative and inflammatory disorder. Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed11181079 Pubmed12711469 Reactome Database ID Release 43211874 Reactome, http://www.reactome.org ReactomeREACT_13626 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54