acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006). Authored: D'Eustachio, P, 2009-12-09 EC Number: 6.2.1.1 Edited: D'Eustachio, P, 2010-02-18 Pubmed16788062 Reactome Database ID Release 43449911 Reactome, http://www.reactome.org ReactomeREACT_21284 Reviewed: Jassal, B, 2010-02-26