Haldane Effect Authored: May, B, 2011-04-04 Edited: May, B, 2011-04-04 Hemoglobin A Binds Oxygen and Releases Protons and Carbon Dioxide Pubmed1395 Pubmed16994616 Pubmed20162361 Pubmed2506737 Pubmed3119859 Pubmed3938604 Pubmed4203704 Pubmed4514311 Pubmed4975618 Pubmed6417382 Pubmed7541176 Reactome Database ID Release 431247668 Reactome, http://www.reactome.org ReactomeREACT_120816 Reviewed: Jassal, B, 2012-04-27 The binding of oxygen (O2) to hemoglobin (HbA) decreases the affinity of HbA for protons (H+) bound at histidine residues and carbon dioxide (CO2) bound chemically as a carbamate at the N-terminus of the HbA (Ferguson and Roughton 1934, Kernohan & Roughton 1968, Klocke 1973, Morrow et al. 1973, Morrow et al. 1976, Tazawa et al. 1983, Kraan & Rispens 1985, Doyle et al. 1987, Mertzlufft & Brandt 1989, Kalhoff et al.1994, Dash & Bassingthwaighte 2010, reviewed in Jensen 2004). This property of HbA is known as the Haldane Effect and facilitates the exchange of CO2 for O2 in the lungs. Protonated Carbamino DeoxyHbA OxyHbA