H+ + HCO3- -> H2O + CO2 Authored: May, B, 2011-03-24 Carbonic Anhydrase IV Dehydrates Bicarbonate to Yield Water and Carbon Dioxide Carbonic anhydrase IV (CA4) located on the extracellular face of the plasma membrane (Wistrand et al. 1999) dehydrates bicarbonate (HCO3--) to yield water and carbon dioxide (CO2) (Zhu & Sly 1990, Okayuma et al. 1992, Baird et al. 1997, Innocenti et al. 2004, reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible. EC Number: 4.2.1.1 Edited: May, B, 2011-03-24 Pubmed10090333 Pubmed1311094 Pubmed15501038 Pubmed2111324 Pubmed9054574 Pubmed9336012 Reactome Database ID Release 431237059 Reactome, http://www.reactome.org ReactomeREACT_120877 Reviewed: Jassal, B, 2012-04-27