abacavir [extracellular] => abacavir [cytosol] Authored: D'Eustachio, P, 2012-03-14 Edited: D'Eustachio, P, 2012-03-16 OCT (organic cation transporter)-mediated abacavir uptake Organic cation transporters 1 (OCT1, SLC22A1), 2 (OCT2, SLC22A2) and 3 (OCT3, SLC22A3) associated with the plasma membrane all mediate the influx of abacavir. The three transporters have similar affinities for abacavir (Minuesa et al. 2009) but differ in the tissues in which they are expressed and in their distributions on the surfaces of polarized cells (reviewed by Klaasen and Aleksunes 2010). Pubmed19141712 Pubmed20103563 Reactome Database ID Release 432161500 Reactome, http://www.reactome.org ReactomeREACT_121207 Reviewed: Jassal, B, 2012-03-16