Calcium Binds Caldesmon Authored: Gillespie, ME, 2003-07-01 00:00:00 Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding. Edited: Gillespie, ME, 2009-03-10 20:55:39 Pubmed11457814 Pubmed1930128 Reactome Database ID Release 43445704 Reactome, http://www.reactome.org ReactomeREACT_20643 Reviewed: Rush, MG, 2008-01-11 00:00:00 Calcium Bound Myosin Actin Complex Inactive Myosin Actin Contractile Complex