unfolded protein:(GlcNAc)2 (Man)8a unfolded protein:(GlcNAc)2 (Man)7aa unfolded protein:(GlcNAc)2 (Man)8a unfolded protein:(GlcNAc)2 (Man)7aa Glycoproteins with major folding defects are sent to degradation by EDEMs Authored: Dall'Olio, GM, 2010-11-18 Edited: Jassal, B, 2010-11-16 Proteins with major folding defects are extracted from futile folding cycles in the calnexin chaperone system and the ER Quality Control Compartment, and are translocated back to the citosol for degradation. The N-glycan is used as a signal to distinguish proteins to be degraded, upon recognition by EDEM1, EDEM2 and EDEM3, three ER-stress-induced members of the glycosyl hydrolase 47 family (see Olivari S, Molinari M 2007 for a review) and OS9 (Mikami K, 2010; Hosokawa N, 2009).<br><br> Pubmed17499246 Reactome Database ID Release 431018376 Reactome, http://www.reactome.org ReactomeREACT_25207 Reviewed: Gagneux, P, 2010-11-18