(un)folded protein:(GlcNAc)2 (Man)9 unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 Re-addition of a glucose on the alpha 1,3 branch Authored: Dall'Olio, GM, 2009-11-10 Edited: Jassal, B, 2010-03-15 Pubmed10694380 Pubmed12913004 Pubmed18426978 Reactome Database ID Release 43548884 Reactome, http://www.reactome.org ReactomeREACT_25264 Reviewed: Gagneux, P, 2010-11-18 The enzymes UGGT1 and UGGT2 are able to distinguish proteins with minor folding defects in the ERQC and reglucosylate them, by adding a glucose on the alpha 1,3 branch (Arnold SM et al, 2000; Arnold SM et al, 2003). The major affinity of these enzymes for proteins with minor folding defects has been demonstrated, but the exact mechanism that enable them to distinguish proteins with major and minor defects is still unknown (Pearse BR et al, 2008).