Addition of a third glucose to the N-glycan precursor by an ALG10 homologue Authored: Dall'Olio, GM, 2009-11-10 Edited: Jassal, B, 2009-11-10 Pubmed15710750 Pubmed9597543 Reactome Database ID Release 43446194 Reactome, http://www.reactome.org ReactomeREACT_22406 Reviewed: Gagneux, P, 2010-04-16 The last glucose is added to the N-glycan precursor. This reaction occurs inside the ER lumen and uses Dol-P-Glc as the glucose donor. In yeast, this reaction is catalyzed by ALG10 (Burda P and Aebi M,1998); however, this gene is duplicated in primates (Ciccarelli FD et al, 2005; Table 1), leading to two homologues, ALG10A and ALG10B, and to date there is no clear evidence to say which of these two paralogues (or both) is responsible for catalyzing this reaction in humans. No Congenital Disorders of Glycosylations are known to be associated with either gene.<br>